Department of Plastic Reconstructive and Aesthetic Surgery, Faculty of Medicine, Universitas Airlangga, Indonesia
Jl. Mayjend Prof. Dr. Moestopo, No. 6-8, Surabaya, 60285.
We are now accepting submissions for the upcoming issue of Jurnal Rekonstruksi dan Estetik, Faculty of Medicine, Universitas Airlangga!
Open for original articles, case reports series, review articles, literature reviews, and meta-analyses.
Scope: * Burn and wound care * Hand surgery * Microsurgery * Oncoplastic surgery * Craniofacial reconstruction * External genitalia reconstruction * Aesthetic
Proud Achievement: Jurnal Rekonstruksi dan Estetik Achieves SINTA 3 Accreditation
We are proud to announce that Jurnal Rekonstruksi dan Estetik (JRE) has been officially accredited at SINTA 3, a national recognition granted by the Ministry of Higher Education, Science, and Technology of the Republic of Indonesia.
This accreditation is based on the Decree of the Directorate General for Research and Development No. 286/DST/C3/HM.01.00/2026, issued on 7 April 2026. The accreditation applies retroactively from Volume 8 Number 1 (2023) and will remain valid until Volume 12 Number 2 (2027).
This milestone represents a significant step forward in our continuous efforts to maintain and enhance the quality of scholarly publishing, particularly in the fields of plastic reconstructive and aesthetic surgery. It reflects our strong commitment to upholding rigorous peer-review standards, ethical publication practices, and the dissemination of impactful scientific knowledge.
We would like to express our sincere appreciation to our editorial board members, reviewers, authors, and the broader academic community for their invaluable contributions, trust, and collaboration. Your support has been instrumental in achieving this recognition.
Moving forward, JRE remains dedicated to fostering high-quality research and supporting both academic advancement and clinical practice. We warmly invite researchers, clinicians, and scholars to contribute their work and be part of our growing scientific community.
For more information and submission guidelines, please visit our official website:
🔥 Does Timing Matter in Burn Wound Grafting? Evidence from a Meta-Analysis
Burn injuries remain a major global health burden, with more than 265 million cases annually worldwide. Surgical skin grafting is a cornerstone in burn management, yet the optimal timing of grafting, whether early or delayed continues to be debated, especially in settings with limited resources.
This systematic review and meta-analysis published in Jurnal Rekonstruksi dan Estetik (JRE) evaluates the clinical and functional outcomes of early versus delayed wound grafting in burn patients.
📄 Article Title: Comparative Outcomes of Early Versus Delayed Wound Grafting in Burn Patients: A Systematic Review and Meta-Analysis 🔗 DOI: https://doi.org/10.20473/jre.v10i2.75022
📌 Why This Study Matters
Early excision and grafting,traditionally performed within 48 hours to 7 daysis believed to:
Reduce infection risk
Shorten hospital stay
Improve functional recovery
Lower morbidity and mortality
However, factors such as hemodynamic instability, inadequate resuscitation, and limited surgical resources often delay intervention, particularly in low- and middle-income countries. This study provides evidence-based guidance to support clinical decision-making.
🔍 Methods at a Glance
Study design: Systematic review and meta-analysis
Search period: July 2024 – January 2025
Study types included:
Randomized controlled trials
Cohort studies
Observational studies
Comparison groups:
Early grafting (within 3–7 days)
Delayed grafting (after 7 days)
Outcomes assessed:
Length of hospital stay
Infection rates
Blood loss
Limb and hand function (TAM & grip strength)
📊 Key Results
250 studies identified, 7 studies met inclusion criteria
Hospital stay:
Early grafting significantly reduced hospitalization by 8.89 days (95% CI: −12.88 to −4.89)
Functional outcomes:
Early grafting showed significantly better Total Active Movement (TAM) MD: 22.10(95% CI: 17.95 to 26.24)
Other outcomes:
No statistically significant differences between early and delayed grafting in:
Blood loss
Infection rates
Post-operative grip strength
🧠 Clinical Interpretation
✅ Early wound grafting offers clear benefits in:
Faster recovery
Shorter hospital stay
Improved postoperative limb mobility
⚠️ However, early grafting did not significantly outperform delayed grafting in terms of infection rates or blood loss, highlighting the importance of patient condition and surgical readiness rather than timing alone.
🎯 Key Takeaways
Early grafting improves functional recovery and hospitalization outcomes
Timing should be balanced with patient stability and resource availability
Supports early intervention when clinically feasible
Calls for further high-quality studies to refine timing protocols
📚 Published in: Jurnal Rekonstruksi dan Estetik ✍️ Authors: Rafeni Bunga, Beta Subakti Nata’admaja 🏥 Affiliations:
✨ Exploring Snail Mucus as a Novel Bioactive Agent in Wound Repair
Wound healing is a complex biological process that requires a coordinated interaction between inflammation control, collagen synthesis, angiogenesis, and tissue remodeling. Despite advances in wound care, delayed healing remains a significant clinical challenge prompting ongoing exploration of natural bioactive substances that can support tissue regeneration.
A recent article published in Jurnal Rekonstruksi dan Estetik systematically evaluates the therapeutic potential of snail mucus extract as a wound-healing agent through a systematic review and meta-analysis of randomized controlled trials (RCTs).
Proteins play a pivotal role in wound repair, mediating cellular migration, extracellular matrix formation, and tissue remodeling. Snail mucins, large glycosylated proteins found in snail mucus, have been reported to:
Stabilize protein structures
Enhance cell–cell recognition
Modulate viscosity and solubility
Promote collagen production
Reduce inflammatory responses
This study provides a rigorous evidence-based evaluation of these proposed benefits.
🔍 Key Findings from the Meta-Analysis
🔹 Study Design and Methodology
Meta-analysis of randomized controlled trials
Databases searched:
PubMed
ProQuest
Web of Science
ScienceDirect
Scopus
EBSCOHost
ClinicalTrials.gov
Methodological framework:
PRISMA guidelines
PICO framework
Quality assessment using the JADAD scale
🔹 Quantitative Results
3 RCTs (2021–2023)
Total of 60 animal subjects (rats)
Snail mucus group showed a significantly faster wound healing rate compared to controls:
Mean Difference (MD): −3.21%
95% CI: −3.72 to −2.69%
P < 0.00001
These results indicate a robust and statistically significant effect.
🧬 Biological Mechanisms Behind Snail Mucus
The bioactive components of snail mucus contribute to wound healing by:
Enhancing collagen synthesis
Reducing local inflammation
Supporting cellular proliferation and migration
Improving tissue remodeling dynamics
These mechanisms align well with modern principles of regenerative medicine and biomaterial-based wound therapy.
⚠️ Translational Considerations
While the findings strongly support the wound-healing efficacy of snail mucus in animal models, the authors emphasize the need for:
Well-designed clinical trials
Standardized formulations
Safety and dosage evaluations in humans
🎯 Why This Article Is Worth Reading and Citing
Provides pooled quantitative evidence via meta-analysis
Highlights snail mucus as a promising natural wound-healing agent
Integrates molecular rationale with experimental outcomes
Relevant to plastic surgeons, wound care specialists, and regenerative medicine researchers
Opens avenues for future translational and clinical research
📚 Published in: Jurnal Rekonstruksi dan Estetik ✍️ Authors: Febe Alodia Widjaja et al. 🏥 Affiliations: Universitas Airlangga, Universitas Airlangga Hospital, Dr. Soetomo General Academic Hospital, University of Twente
